Figure 9.

Schematic representation of the main cellular pathways that depend on apicoplast Fe-S proteins. For selected apicoplast-located Fe-S proteins, squared red numbers represent CRISPR fitness score of the corresponding gene (genes that contribute to in vitro parasite fitness are represented by negative scores; values below −2.5 highlight increasing likelihood of being essential). CoA, coenzyme A; dol-P, dolichol phosphate; DMAPP, dimethylallyl diphosphate; FASII, fatty acid synthesis type II; Fd, ferredoxin; Fe-S, iron-sulfur; FPP, farnesyl diphosphate; GPP, geranyl diphosphate; GGPP, geranylgeranyl diphosphate; GPI, glycosylphosphatidylinositol; IPP, isopentenyl diphosphate; IspG/IspH, oxidoreductases catalyzing the last two steps of IPP/DMAPP synthesis; LipA, lipoyl synthase; PDH-E2, E2 subunit of the pyruvate dehydrogenase complex.