TABLE 3.
Factors relating to the 28-day mortality risk in patients with sepsis by logistic regression model analysis.
| Items | P-value | OR | 95%CI | |
|
|
||||
| Lower | Upper | |||
| Univariate logistic regression | ||||
| MiR-451a | <0.001 | 1.777 | 1.286 | 2.455 |
| Th1/Th2 ratio | <0.001 | 2.238 | 1.455 | 3.441 |
| Th1 | 0.002 | 1.215 | 1.076 | 1.373 |
| Th2 | 0.045 | 0.786 | 0.620 | 0.995 |
| Age | 0.904 | 1.002 | 0.966 | 1.040 |
| Gender (Male vs. Female) | 0.590 | 1.307 | 0.493 | 3.462 |
| BMI | 0.251 | 1.072 | 0.952 | 1.206 |
| Smoke (Yes vs. No) | 0.222 | 0.677 | 0.362 | 1.266 |
| Drink (Yes vs. No) | 0.229 | 1.731 | 0.708 | 4.233 |
| History of hypertension (Yes vs. No) | 0.318 | 1.575 | 0.646 | 3.840 |
| History of hyperlipidemia (Yes vs. No) | 0.079 | 2.593 | 0.895 | 7.507 |
| History of diabetes (Yes vs. No) | 0.171 | 2.306 | 0.696 | 7.634 |
| History of CKD (Yes vs. No) | 0.912 | 0.913 | 0.181 | 4.598 |
| History of CCVD (Yes vs. No) | 0.627 | 1.298 | 0.453 | 3.719 |
| Primary infection site | ||||
| Abdominal infection | Ref. | |||
| Respiratory infection | 0.057 | 3.167 | 0.964 | 10.398 |
| Skin and soft tissue infection | 0.317 | 2.000 | 0.515 | 7.764 |
| Other infections | 0.085 | 3.455 | 0.844 | 14.144 |
| Primary organism | ||||
| G- bacteria (Yes vs. No) | 0.018 | 0.330 | 0.131 | 0.827 |
| G + bacteria (Yes vs. No) | 0.750 | 0.846 | 0.303 | 2.362 |
| Fungus (Yes vs. No) | 0.051 | 3.583 | 0.994 | 12.923 |
| Others (Yes vs. No) | 0.261 | 0.413 | 0.088 | 1.931 |
| Total culture negative (Yes vs. No) | 0.001 | 5.906 | 1.981 | 17.605 |
| APACHE II score | 0.004 | 1.124 | 1.039 | 1.216 |
| SOFA score | <0.001 | 2.019 | 1.501 | 2.715 |
| SOFA score-respiratory system | <0.001 | 7.820 | 3.017 | 20.271 |
| SOFA score-nervous system | 0.392 | 1.456 | 0.616 | 3.439 |
| SOFA score-cardiovascular system | 0.005 | 3.263 | 1.421 | 7.495 |
| SOFA score-liver | 0.011 | 2.752 | 1.266 | 5.982 |
| SOFA score-COAGULATION | 0.019 | 2.875 | 1.192 | 6.937 |
| SOFA score-renal system | 0.001 | 4.102 | 1.779 | 9.459 |
| TNF-α (pg/mL) | 0.077 | 1.004 | 1.000 | 1.008 |
| IL-1β (pg/mL) | 0.263 | 1.069 | 0.951 | 1.202 |
| IL-6 (pg/mL) | 0.366 | 1.013 | 0.985 | 1.041 |
| CRP (mg/L) | 0.001 | 1.012 | 1.005 | 1.019 |
| Multivariate logistic regression (Step forward method) | ||||
| Th1/Th2 ratio | 0.005 | 2.052 | 1.243 | 3.386 |
| G- bacteria (Yes vs. No) | 0.037 | 0.191 | 0.040 | 0.908 |
| SOFA score | 0.002 | 1.867 | 1.265 | 2.756 |
OR, odds ratio; CI, confidence interval; MiR-451a, microRNA-451a; Th1, T helper 1 cells; Th2, T helper 2 cells; BMI, body mass index; CKD, chronic kidney disease; CCVD, cardiovascular and cerebrovascular diseases; G-, Gram-negative; G +, Gram-positive; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; TNF-α, tumor necrosis factor-alpha; IQR, interquartile range; IL-1β, interleukin-1beta; IL-6, interleukin 6; CRP, C-reactive protein. The bold values represent statistical significance.