Table 6.
The summary table of comparisons between adults and children.
| Subgroup | Adults | Children | P-value | ||
|---|---|---|---|---|---|
| Cumulative incidence | 95% CI | Cumulative incidence | 95% CI | ||
| SR-aGVHD | |||||
| ORR | |||||
| At any time | 0.75 | 0.62–0.84 | 0.75 | 0.51–0.90 | 0.960 |
| CRR | |||||
| At any time | 0.48 | 0.42–0.54 | 0.41 | 0.20–0.66 | 0.601 |
| At day 28 | 0.32 | 0.24–0.41 | 0.21 | NA | NA |
| Infection | 0.75 | 0.66–0.82 | 0.86 | 0.64–0.95 | 0.296 |
| Viral infection | 0.59 | 0.59–0.71 | 0.45 | 0.31–0.60 | 0.193 |
| Cytopenia | |||||
| Grades I–IV | 37.3 | 0.0–82.1 | 53.8 | NA | NA |
| Anemia | |||||
| Grades I–IV | 24.7 | 0.0–55.3 | 25.0 | NA | NA |
| Grades III–IV | 26.0 | 7.0–45.0 | 25.0 | NA | NA |
| Leukopenia | |||||
| Grades I–IV | 34.3 | 0.6–68.1 | 26.0 | 0.0–100.0 | 0.645 |
| Grades III–IV | 28.0 | 14.8–41.2 | 26.0 | 0.0–100.0 | 0.904 |
| Thrombocytopenia | |||||
| Grades I–IV | 23.7 | 0.0–56.7 | 19.8 | 0.0–41.8 | 0.722 |
| Grades III–IV | 31.0 | 0.0–73.2 | 30.5 | 0.0–100.0 | 0.975 |
| SR-cGVHD | |||||
| ORR | |||||
| At any time | 0.81 | 0.76–0.85 | 0.89 | 0.75–0.95 | 0.222 |
| CRR | |||||
| At any time | 0.18 | 0.10-0.30 | 0.11 | 0.04 –0.26 | 0.359 |
| Infection | 0.37 | 0.18–0.61 | 0.42 | NA | NA |
| Anemia | |||||
| Grades I–IV | 20.7 | 0.0–57.9 | 8.3 | NA | NA |
| Grades III–IV | 5.0 | 0.0–15.6 | 0.0 | NA | NA |
| Leukopenia | |||||
| Grades I–IV | 11.5 | 2.6–20.4 | 8.3 | NA | NA |
| Grades III–IV | 9.8 | 2.3–17.3 | 0.0 | NA | NA |
| Thrombocytopenia | |||||
| Grades I–IV | 7.0 | 0.0–17.6 | 8.3 | NA | NA |
| Grades III–IV | 3.8 | 0.0–8.3 | 0.0 | NA | NA |