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. 2022 Aug 4;13:954268. doi: 10.3389/fimmu.2022.954268

Table 8.

Myelosuppression after ruxolitinib treatment.

Subgroup Total Adults Children
Cumulative incidence 95% CI Cumulative incidence 95% CI Cumulative incidence 95% CI
SR-aGVHD
Cytopenia
 Grades I–IV 53.2 16.0–90.4 37.3 0.0–82.1 53.8 NA
 Grades III–IV 31.0 0.0–100.0 16.5 0.0–100.0 NA NA
Anemia
 Grades I–IV 45.6 19.8–71.5 24.7 0.0–55.3 25.0 NA
 Grades III–IV 37.3 18.4–56.3 26.0 7.0-45.0 25.0 NA
Leukopenia
 Grades I–IV 44.2 24.4–64.0 34.3 0.6–68.1 26.0 0.0–100.0
 Grades III–IV 36.8 20.7–52.9 28.0 14.8–41.2 26.0 0.0–100.0
Thrombocytopenia
 Grades I–IV 40.6 21.4–59.8 23.7 0.0–56.7 19.8 0.0–41.8
 Grades III–IV 42.4 25.0–59.7 31.0 0.0–73.2 30.5 0.0–100.0
SR-cGVHD
Cytopenia
 Grades I–IV 28.8 13.0–44.6 28.3 4.8–51.7 NA NA
 Grades III–IV 10.4 0.0–27.9 21.0 0.0–100.0 NA NA
Anemia
 Grades I–IV 35.1 13.2–57.0 20.7 0.0–57.9 8.3 NA
 Grades III–IV 11.2 2.1–20.3 5.0 0.0–15.6 0.0 NA
Leukopenia
 Grades I–IV 22.9 6.2–39.6 11.5 2.6–20.4 8.3 NA
 Grades III–IV 8.9 4.7–13.1 9.8 2.3–17.3 0.0 NA
Thrombocytopenia
 Grades I–IV 19.2 6.9–31.6 7.0 0.0–17.6 8.3 NA
 Grades III–IV 10.2 3.6–16.8 3.8 0.0–8.3 0.0 NA

CI, confidence interval; NA, not available; SR-aGVHD, steroid-refractory acute graft-versus-host disease; SR-cGVHD, steroid-refractory chronic graft-versus-host disease.