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. 2022 Aug 10;42(8):BSR20220994. doi: 10.1042/BSR20220994

Figure 3. MLN4924 inhibited the proliferation and induced the apoptosis of AML cells.

Figure 3

(A) MLN4924 significantly inhibited the proliferation of THP-1 cells, MOLM-13 cells and the primary cells collected from two AML patients in a concentration- and time-dependent manner. (B–E) The numbers of apoptotic cells of THP-1 and MOLM-13 cells significantly increased following treatment with MLN4924 (except for the 0.1 μM dose group of MLN4924 in MOLM-13 cells, P>0.05). (F–H) MLN4924 induced cell cycle arrest in both THP-1 and MOLM-13 cells at the G2/M phase, and significantly increased the cells at G2/M phase; ***P<0.001. The means among multiple groups were compared by one-way ANONA and LSD-t test. Each experiment was carried out in triplicate.