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. 2022 Aug 10;42(8):BSR20220994. doi: 10.1042/BSR20220994

Figure 4. MLN4924 inhibited the NEDDylation of CULs in AML cells.

Figure 4

(A) MLN4924 significantly inhibited the NEDD8 NEDDylation of CUL1-5 in THP-1 cells. (B) In MOLM-13 cells, the NEDDylation of CUL1-5 was also inhibited. (C) MLN4924 inhibited the NEDD8 NEDDylation of CUL1-5 in primary AML cells collected from two AML patients. (D–G) Statistical analysis revealed that MLN4924 inhibited the NEDD8 NEDDylation of CULs in THP-1 cells; ***P<0.001, **P<0.01. An independent sample t-test was adopted to compare the means between two groups. Each experiment was conducted in trplicate.