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. 2022 Aug 10;42(8):BSR20220994. doi: 10.1042/BSR20220994

Figure 5. MLN4924 activated the p53 signaling pathway in AML cells.

Figure 5

(A,B) In THP-1 and MOLM-13 cells, the expression levels of p21 and p53 proteins were significantly up-regulated after MLN4924 treatment. (C) In primary AML cells harvested from two AML patients, MLN4924 increased the expression of both p21 and p53 proteins. (D,E) Statistical analysis indicated that the expression of p21 and p53 was up-regulated; ***P<0.001, **P<0.01. An independent sample t-test was conducted to compare the means between two groups. Each experiment was carried out in triplicate.