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. Author manuscript; available in PMC: 2022 Aug 18.
Published in final edited form as: Ultrasound Med Biol. 2020 Sep 8;46(12):3379–3392. doi: 10.1016/j.ultrasmedbio.2020.08.009

Table 3.

Description of the four liver groups. This study was designed to use fibrosis inducers to cause liver disease. The total of 35 rats includes 31 SD and 4 nude rats, and all nude rats were confirmed as fibrotic with low fat. The four confirmed states by pathology are considered as desired classes in SVM classifier. Each rat has approximately 30 ultrasound scan frames, resulting in 998 frames for training set.

Dosing Confirmed state Oil Red O stain area [%, mean ± SD] Number
controls or vehicle controls (olive oil PO) Normal 1.2 ± 1.5 9
CCl4 Fibrosis with low fat* 2.9 ± 1.9 11
CCl4 Fibrosis with high fat* 17.3 ± 11.2 6
ConA Inflammation** 0.7 ± 1.6 9
*

Fibrosis with low and high fat are classified by Oil Red O stain area compared to tissue stained area (%). Fibrosis with low and high fat have the ratio less than 6.5% and greater than 9%, respectively.

**

Inflammation group has no fibrosis and very low fat, which is comparable to normal group.