Table 1.

Visual synopsis of CF animal models discussed in this review as referenced to current CF research priorities (CFTR restoration, mucus biology, infection, inflammation, and GI disease). Green check mark indicates documented use through published reports (selected references are provided), red cross mark indicates untested or unsuitable application (for example, absence of spontaneous phenotype), blue question mark indicates applications under development or restricted to a particular variant of the animal model (for example, humanized variant).