. 2021 Feb 10;116:107791. doi: 10.1016/j.yebeh.2021.107791

Table 1.

Mechanistic insights determined for the relationship between raised body temperature and seizures.

Raised body temperature and seizures: possible mechanisms (different combinations may be relevant depending on the cause of the raised body temperature)
Genetic susceptibility (channelopathies)	Voltage-gated Na⁺ channels (SCN1B, SCN1A)
	GABA-A ligand-gated/receptor-coupled ion channel subunits
	Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
Change in permeability of native ion channels	Temperature-sensitive TRPV channels
Change in permeability of native ion channels	L-type Ca²⁺ channels (Cav1.2 subunit)
Activation of the innate immune system	Pro-inflammatory cytokines (IL-1β, TNF)
Induction of hyperventilation	Alkalosis