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. 2022 Aug 18;20:255. doi: 10.1186/s12916-022-02457-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Heat map of the clustering analysis. Samples of PPAT categorized by ISUP group naturally clustered into experimental studied groups: low-risk (group I) and high-risk (groups III, IV, and V). Metabolite intensities are displayed as colors ranging from red grading (more abundant metabolites) to blue grading (less abundant metabolites). Classification of lipid according to extraction method: FAME: ω-6 PUFA, SFA, total PUFA, and behenic acid. LIP-I: 13-OxoODE/9oxoODE; 12,13-EpOME; LPI, lauric acid and linoleic acid. LIP-II: MG, and TG