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. 2022 Aug 18;20:255. doi: 10.1186/s12916-022-02457-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — A bidirectional crosstalk occurs between PPAT explants and PCa cell lines. PCa cell lines (PC-3 or LNCaP) were co-cultivated with PPAT explants for 48 h and expression of lipid-, inflammatory-, and tumor-related genes were evaluated by RT-qPCR. A Co-cultured explants with LNCaP or PC-3 cells. B Co-cultured PC-3 cells. C Co-cultured LNCaP cells. D Uptake of the fatty acid analog TF2-C12 at 30 and 60 min in PCa cell lines co-cultured with PPAT explants. E Lipid accumulation measured with Nile Red dye after 15-min incubation in PCa cell lines co-cultured with PPAT explants. Different lettering over the boxes indicates statistical differences. Significant differences are established at p < 0.05. Data are expressed as mean ± SEM (n = 6 experiments)