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. 2022 Aug 18;19:57. doi: 10.1186/s12989-022-00497-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — In vivo effect of temperature on breathing rate in unexposed and prenatally TiO₂ NP-exposed neonates. A Schematic of experimental procedure. B Whole-body plethysmographic recordings of non-exposed (Control, green traces) and TiO₂ NP (200 µg/g)-exposed offspring (purple traces) under different ambient temperature conditions (indicated between traces). C Bar charts showing values of body temperature under standard room temperature in control (green bar) and TiO₂ NP (200 µg/g)-exposed offspring (purple bar). D Bar charts illustrating changes in spontaneous breathing frequency (mean ± SEM) in control (green bars) and prenatally TiO₂ NP-exposed (purple bars) groups under the warming protocol. Data were pooled from P0 to P3. ***p < 0.001; ns, not statistically significant