Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 17;17:52. doi: 10.1186/s13024-022-00554-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Differential expression profiles between PD/GBA, CTRL/GBA, and PD. a-b PD/GBA vs CTRL/GBA. a Volcano plot represents log₂ fold change (log2FC) (x-axis) and -log₁₀ of P-values (y-axis) of the differentially expressed genes between PD/GBA and CTRL/GBA groups. Green dots represent genes with FDR < 0.05. Selected genes were highlighted based on overlap targeted pathways as indicated in the legend on the right side. b Pathway enrichment analysis of differentially expressed genes between PD/GBA vs CTRL/GBA subjects. Pathway enrichment of genes differentially expressed between PD/GBA and CTRL/GBA subjects with FDR < 0.05 for GO terms are reported. Light blue: pathways related to the immune response; Dark green: pathways related to exocytosis; Light green: pathways related to RNA metabolism; Dark blue: other pathways. c-d PD/GBA vs PD. c Differential normalized expression count of SNCA and LMNA between PD/GBA and PD. Disease and genetic status are reported on the x-axes. Each dot represents a subject. Dots are colored based on GBA mutations (as reported in the legend: GBA mild mutations (N370S, E326K, R496H), GBA severe mutations (L444P/A456P/RecNciI, V394L, 84GG, 84GG/T369M, N370S/RecNciI)). Asterisks indicate significant adjusted p-value (* = adjusted p-value < 0.05, ** = adjusted p-value < 0.01, *** = adjusted p-value < 0.001; statistics: Mann-Whitney U test). d Schematic representation (STRING, [150]) of functionally relevant genes differentially expressed between PD/GBA and PD cohorts. Genes are grouped in colored circles based on shared functional pathways (yellow: amyloid-related genes, blue: SNCA-related genes, grey: PD hits related genes). Arrows indicate whether genes are up (green) or down (red) regulated in the PD/GBA vs the PD cohort