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. 2022 Aug 17;17:52. doi: 10.1186/s13024-022-00554-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Differential expression profiles in whole blood and overlap with monocytes data. a Upset plot summarizing the number of differentially expressed genes at FDR < 0.05 in whole blood between manifesting and non-manifesting GBA carriers, and PD and CTRL subjects and the overlapping genes with monocytes. b Number of DEG across groups in whole blood (UP = upregulated genes, DOWN: downregulated genes). c Dysregulated pathways in CD14+ monocytes and whole blood in GBA/PD vs GBA/CTRL. The plot represent the -log₁₀(P Value) the enriched pathways in the differentially up-regulated and down-regulated genes when comparing GBA/PD vs GBA/CTRL in both isolated CD14+ monocytes (blue) and whole blood (yellow) at FDR 5%. The figure shows an overlap in monocytes and whole blood of the upregulated pathways related to membrane trafficking and immune response