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. 2022 Aug 17;10:116. doi: 10.1186/s40478-022-01416-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Impact of PMX205 on microglia-plaque interaction in the Tg2576 mouse model of Alzheimer’s disease. A Representative immunohistochemical images of amyloid plaques 6E10: green), microglial cells (Iba1: blue) and microglial lysosomes (CD68: red) in the Tg2576-vehicle (A1-A6) and Tg2576-PMX205 (A7-A12). Imaris 3D-reconstruction images showed a trend towards reduced internalization of Amyloid-ß by microglial cells (A6 and A12) in the Tg2576-PMX205 mice when compared to the vehicle treated group. B Representative images of amyloid plaques (6E10: green) and microglial cells (Iba1: blue) in the Tg2576-vehicle (B1-B4) and Tg2576-PMX205 (B7-B10). Tridimensional reconstruction images (B5-B6 and B11-B12) and quantification showed no difference in the engagement of microglial cells around amyloid plaques between the PMX205 treated group and the controls. Data are shown as Mean ± SEM and normalized to control group (Tg2576-PMX205). Statistical analysis used a two-tailed t-test. 15 amyloid plaques/mouse and n = 4–5 per group. Scale bar: 10 µm