Table 1.

Histopathological findings in the liver

Age at the end of dosing:		8 weeks				10 weeks
Dose (mg/kg):		0	3.13	6.25	12.5	0	3.13	6.25	12.5
Findings	No. of animals examined:	5	5	5	5	5	5	5	5
Single cell necrosis, hepatocytes, centrilobular		0	4	5	5	0	3	5	5
minimal		–	4	3	–	–	3	2	–
mild		–	–	2	5	–	–	3	5
Karyomegaly, hepatocyte, centrilobular		0	3	5	5	0	3	5	5
minimal		–	3	2	–	–	3	2	–
mild		–	–	3	4	–	–	3	3
moderate		–	–	–	1	–	–	–	2
Mitosis, increased, hepatocyte		0	0	2	5	0	0	2	5
minimal		–	–	2	5	–	–	2	4
mild		–	–	–	–	–	–	–	1

–: no finding in this grade