TABLE 2.
Receptor expression for IMAT‐derived factors with significantly higher secretion compared to SAT and VAT
| IMAT‐secreted factors | Uniprot ID | Receptor/s | Receptor‐expressing cell type in skeletal muscle |
|---|---|---|---|
| IL2 | P60568 | IL‐2R α/β/γ | Skeletal myotubes (Yoshida et al., 2022), T‐cells, macrophages |
| IL18 | Q14116 | IL‐18Rα/β | Endothelial cells, macrophages, neutrophils |
| IL27 | Q8NEV9 | IL‐27Rα, GP130 | Endothelial cells, macrophages, neutrophils |
| FGF23 | Q9GZV9 | FGFR1, Klotho | Satellite cells (Kästner et al., 2000), skeletal myotubes (Avin et al., 2018), endothelial cells fibroblasts, macrophages |
| CSF1 | P09603 | CSF1R | Endothelial cells, fibroblasts, macrophages |
| IL10 | P22301 | IL‐10Rα/β | Skeletal myoblasts (Strle et al., 2007), endothelial cells, fibroblasts, macrophages, neutrophils |
| IL13 | P35225 | IL‐13Rα1, IL‐4Rα | Skeletal myotubes (Prokopchuk et al., 2007), endothelial cells, macrophages, neutrophils |
| IL8 | P10145 | CXCR1, CXCR2 | Skeletal myotubes (Sell et al., 2006), neutrophils |
| CCL11 | P51671 | CCR2, CCR3, CCR5 | Skeletal myotubes (Sell et al., 2006), macrophages |
| MCP1 | Q6UZ82 | CCR2, CCR4 | Skeletal myotubes (Sell et al., 2006), macrophages |
| CCL25 | O15444 | CCR9 | Not detected |
| CCL27 | Q9Y4X3 | CCR10 | Skeletal myotubes (Sell et al., 2006), fibroblasts |
| Resistin | Q9HD89 | TLR4, CAP1 | Skeletal myotubes (Radin et al., 2008), endothelial cells, macrophages, neutrophils |
| HGF | P14210 | c‐Met | Satellite cells (Kästner et al., 2000), skeletal myotubes (Gal‐Levi et al., 1998), macrophages |
| TXB2 | n/a | TPα/β | Endothelial cells, fibroblasts |
| 5‐HETE | n/a | OXER1 | Fibroblasts, macrophages |
| 12‐HETE | n/a | GPR31 | Macrophages |
Note: This table includes well‐known receptors and receptor‐expressing cell types in skeletal muscle at the time of publication, and is not meant to be an exhaustive list of all potential ligand/receptor interactions or all cell types that may express the receptors. To provide context for the in vitro and in vivo relationship between intermuscular adipose tissue and skeletal muscle insulin sensitivity references are included for those factors with reported expression on skeletal myotubes.