Table 1: sgRNA shedding on 3 and 5 DPE and 14-day seroconversion of sentinel animals exposed to IN or IT inoculated donors.
Shedding data is for N = 3 for contact and airborne transmission at 16.5 cm. Seroconversion of sentinels was measured by anti-spike SARS CoV-2 IgG ELISA and values are the average of two replicates, diluted 1:100. Cut-off = OD of 0.07 for positivity.
| Sentinel Shedding sgRNA copies/mL (Log10) | Sentinel seroconversion (ELISA) | |||
|---|---|---|---|---|
| Sentinel | Day 3 | Day 5 | Day 14 | |
| IN Donor Contact | 1 | 0.00 | 6.71 | positive |
| IN Donor Contact | 2 | 5.14 | 5.88 | positive |
| IN Donor Contact | 3 | 5.06 | 5.72 | positive |
| IT Donor Contact | 7 | 6.26 | 5.16 | positive |
| IT Donor Contact | 8 | 0.00 | 0.00 | negative |
| IT Donor Contact | 9 | 6.74 | 0.00 | positive |
| IN Donor Air | 4 | 0.00 | 0.00 | negative |
| IN Donor Air | 5 | 0.00 | 0.00 | negative |
| IN Donor Air | 6 | 5.57 | 6.08 | positive |
| IT Donor Air | 10 | 0.00 | 0.00 | negative |
| IT Donor Air | 11 | 0.00 | 0.00 | negative |
| IT Donor Air | 12 | 0.00 | 0.00 | negative |