Table 2. Kinetics of excision of the Rp diastereomer of CMPαS and AMPαS by ExoN.
NMP | rate (min−1) | t1/2 (min) |
---|---|---|
CMP | 0.22 ± 0.010 | 3 |
CMPαS (Rp,Sp) | 0.0016 ± 0.0003 | 350 |
AMP | 0.13 ± 0.02 | 5 |
AMPαS (Rp) | 0.0015 ± 0.0003 | 460 |
NMP | rate (min−1) | t1/2 (min) |
---|---|---|
CMP | 0.22 ± 0.010 | 3 |
CMPαS (Rp,Sp) | 0.0016 ± 0.0003 | 350 |
AMP | 0.13 ± 0.02 | 5 |
AMPαS (Rp) | 0.0015 ± 0.0003 | 460 |