Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2022 Dec 26:2022.08.07.503099. Originally published 2022 Aug 8. [Version 2] doi: 10.1101/2022.08.07.503099

PMC9387136.1; 2022 Aug 8
PMC9387136.2; 2022 Dec 26

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Fig. 5. — (A) Phylogenetic trees for viral genomes with the indicated resistance mutations (GISAID, 6-December-2022). Only the Omicron lineage is displayed for M49I due to the high frequency of this mutation.

(B) Branches of the phylogenetic tree from panel A showing transmission of a Delta lineage isolate with ΔP168 likely from a single founder event.

(C) Frequency of M^pro variants in Omicron lineage compared to all previous viral lineages.

(D) Background luminescence as a proxy for protease activity of different M^pro variants on the P132H (Omicron) background using the live cell Src-M^pro-Tat-fLuc assay.

(E) Dose-response curves for nirmatrelvir and ensitrelvir inhibition of M^pro variants on the P132H (Omicron) background using the live cell Src-M^pro-Tat-fLuc assay.