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. Author manuscript; available in PMC: 2022 Aug 18.
Published in final edited form as: Semin Hematol. 2020 Jun 11;57(1):1–6. doi: 10.1053/j.seminhematol.2020.06.001

Table 1.

Known roles of microbial metabolites in acute graft versus host disease (GVHD)

Microbial metabolites Short chain fatty acids (SCFAs) Aryl hydrocarbon receptor (AhR) ligands Bile Acid metabolite taurine
Known roles in acute GVHD Direct effect of the SCFAs butyrate and propionate on intestinal epithelial cells (IECs) - > reduced severity of experimental acute GVHD lower levels of urine 3- indoxyl sulfate -> increased clinical acute GVHD contributes to the mechanism of NLRP6-mediated GVHD toxicity in mice post allo HSCT