Skip to main content
. 2022 Aug 8;80(6):620–630. doi: 10.1590/0004-282X-ANP-2021-0156

Table 3. Methodological characteristics of studies on the diagnosis and prevalence of autism in DS.

Author, year Inclusion criteria Sample size Age range (years) Autism assessment tools Information sources Reference criterion for diagnosis Diagnostic benchmark prevalence Proportions of men/women
Starr et al. 23 , 2005 Individuals with DS and severe intellectual disability 13 7 to 31 Autism Diagnostic Interview-Revised (ADI-R) and Adapted Pre-Linguistic Autism Diagnostic Observation Schedule (A-PL-ADOS) Parents DSM-IV and CID-10 - 1.16:1
Carter et al. 24 , 2006 Individuals with DS 127 2 to 24 Autism Behavior Checklist and Aberrant Behavior Checklist Parents DSM‐IV - 2.33:1
Hepburn et al. 6 , 2007 Children with SD 20 2 to 3 Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule-Generic Parents DSM-IV TR - 2.45:1
Dressler et al. 18 , 2011 Individuals with DS and/or autism living with their family 24 6 to 34 Childhood Autism Rating Scale (CARS) Parents DSM-IV TR - 0.84:1
Ji et al. 25 , 2011 Individuals with DS 293 2 to 13 Autism Behavior Checklist Not informed DSM-IIIR and DSM-IV - 3.16:1
Magyar et al. 28 , 2012 Individuals with DS 71 4 to 14 Archival Social Communication Questionnaire (SCQ), Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule Not informed DSM-IV - 1.29:1
Pandolfi et al. 7 , 2017 Individuals with DS 71 3 to 15 Pervasive Developmental Disorder in Mental Retardation Scale (PDD- MRS), Social Communication Questionnaire - Lifetime Version (SCQ-L) and Autism Diagnostic Interview-Revised (ADI-R) Parents DSM-IV- TR - 1.15:1
Godfrey et al. 28 , 2019 Individuals with DS born between January 1, 1996, and December 21, 2003, and who had a caregiver who spoke English or Spanish fluently 33 born between 1996 and 2003 Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) Parents DSM-V - 2.01:00
Oxelgren et al. 29 , 2019 Individuals with DS 60 5 to 17 Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) Parents Not informed - 1.8:1
Capone et al. 29 , 2005 Individuals with DS 131 2 to 21 Behavior questionnaires, semi-structured neurological development assessment and observation during play or social interactions Parents DSM-IV 12.9% 2.7:1
DiGuiseppi et al. 8 , 2010 Individuals with DS born between January 1, 1996, and December 21, 2003, and who had a caregiver who spoke English or Spanish fluently 123 2 to 21 Behavior questionnaires, semi-structured neurological development assessment and observation during play or social interactions Parents DSM-IV TR AUT 6.4% TEA 11.8% Total 18.2% 1.86:1
Moss et al. 30 , 2013 Participants were included if there was information on the date of birth and diagnosis of DS from a professional (physician, clinical geneticist, pediatrician or other), if at least 75% of the SCQ (Rutter et al., 2003) had been completed and if the participant with SD was at least 4 years of age. 108 4 to 62 Social Communication Questionnaire (SCQ) Parents Not informed 19% 0.7:1
Warner et al. 31 , 2014 Individuals with DS 160 4 to 40 Lifetime version of the Social Communication Questionnaire (SCQ) and Strengths and Difficulties Questionnaire Parents Not informed AUT 16,5% TEA 37.7% 1.2:1