FIGURE 4.

A bridging theme shared between β‐propeller like domain e3nvqB1 and Trefoil/Plexin‐like domain e1olzA3. (a) Center panel: The two domains are optimally superposed according to the sequence alignment of the themes. Side panels: The structures of e3nvqB1 (left) and e1olzA3 (right) with their themes highlighted in yellow and green. Despite the high sequence identity, the structures of the themes in the two domains differ. (b) Sequence alignment of two variations of the bridging theme shows evidence of homology (35 aligned residues with 51% identity and 71% similarity). The residue numbers of the beginnings and ends of the theme variations, taken from Evolutionary Classification of Domains, are indicated. For clarity, insertions of the discontinuous theme in e3nvqB1 are simply marked as arrows. The numbers before and after the bridging theme represent the number of residues in corresponding regions, 1 and 16, respectively.