FIGURE 5.

RNA‐interaction of the N‐terminal intrinsically disordered region of N^{SARS‐CoV‐2}. (a) Superposition of ¹H‐¹⁵N HSQC spectra of full‐length N^{SARS‐CoV‐2} without polyU RNA and in the presence of 1.5 μM polyU. Spectra were measured at 5°C. (b) ¹H‐¹⁵N HSQC spectra of the N^{SARS‐CoV‐2}‐residue G5 in the presence of 0, 0.05, 0.5, 1.0, and 1.5 μM polyU RNA. (c) Chemical shift perturbation of the NTE upon interaction with 1.5 μM polyU RNA (NTE sequence shown above; unassigned/overlapped residues are displayed in light gray)