Table 3.

Structures of (3-methoxybenzyl)thioureas (series C) and their rat TRPV1 agonist activities as log(1/EC₅₀) (μM) values (reference²⁵).

	R1	R2	log(1/EC50)
C_1a	H	4-Cl-benzyl	1.125
C_1b	H	4-Cl-phenethyl	1.252
C_1c	H	(E)- 4-chlorostyryl	0.387
C_1d	H	(Z)- 4-chlorostyryl	1.387
C_1e	H	4-F-phenethyl	0.886
C_1f	H	2,4-dichlorophenethyl	0.886
C_1g	H	phenethyl	0.319
C_1h	H	3-(4-chlorophenyl)propyl	0.319
C_1i	H	4-(tert-butyl)benzyl	0.292
C_2a	‒(CH2)2-NH2	4-Cl-phenethyl	0.022
C_2b	‒(CH2)2-NH2	phenethyl	−0.435
C_2c	‒(CH2)2-NH2	4-F-phenethyl	−0.362
C_2d	‒(CH2)2-NH2	2,4-dichlorophenethyl	0.495
C_2e	‒(CH2)2-NH2	4-I-benzyl	−0.127
C_2g	‒(CH2)2-NH2	4-(tert-butyl)phenyl	−0.220
C_2h	‒(CH2)2-NH2	4-(tert-butyl)benzyl	0.770
C_2i	‒(CH2)2-NH2	3,5-di-tert-butylbenzyl	0.658
C_2j	‒(CH2)2-NH2	4-(tert-butyl)phenethyl	0.149
C_3	‒(CH2)3-NH2	4-Cl-phenethyl	−0.739
C_4	‒(CH2)2-NH-CH3	4-Cl-phenethyl	−0.847
C_5	‒(CH2)2-N(CH3)2	4-Cl-phenethyl	−0.547
C_8	‒(CH2)2-NH-COCH3	4-Cl-phenethyl	−0.710