Figure 1.

SARS‐CoV‐2 activates complement in whole blood but not in plasma. C5a levels were assessed with an ELISA in SARS‐CoV‐2‐inoculated lepirudin‐anticoagulated (a) human blood at 30 min and 24 h (n = 3, three technical replicates) and (b) plasma at 24 h (n = 5, two technical replicates). Different donors were used in a and b. Columns and whiskers depict mean values and SEM, respectively. MOI, multiplicity of infection; CoV‐2, SARS‐CoV‐2 MOI 1.0; *P < 0.05, **P < 0.01, ****P < 0.0001, using a one‐way ANOVA.