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. Author manuscript; available in PMC: 2022 Dec 24.
Published in final edited form as: Sci Immunol. 2022 Jun 17;7(72):eabn9301. doi: 10.1126/sciimmunol.abn9301

Figure 2. Differential CD8+ T cell immunogenicity of multi-miR-restricted RhCMV/SIV vectors.

Figure 2.

(A-C) Analysis of SIV Gag-specific CD8+ T cell responses elicited by 68–1 RhCMV/SIVgag vectors with multiple miR-mediated tropism restrictions: miR-126 + miR-205 (n = 3 RMs), miR-126 + miR-142 (n = 3 RMs), and miR-126 + miR-142 + miR-205 (n = 1 RM). Analysis was performed as described in Fig. 1. Overall analysis of 15mer peptide responses in all RMs vaccinated with these miR-restricted 68–1 RhCMV/SIV vectors are shown in table S2, with estimated epitope densities shown in table S3.