Table 1:

Effect of miR-mediated tropism restriction on 68-1 RhCMV/SIV vector urine shedding, CD8+ T cell response programming and vaccine efficacy

miR restriction	Vector tropism restriction (cell type)	Urine shedding	MHC targeting of vector-elicited CD8+ T cells	SIV efficacy (replication arrest)
none	none	yes	MHC-E and MHC-II	yes
miR-142	myeloid	yes	MHC-II alone	no
miR-126	endothelial	yes	MHC-E alone	yes
miR-205	epithelial	no	MHC-E and MHC-II	not done
miR-142 + miR-126	myeloid + endoth.	not done	MHC-Ia alone	no