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. 2022 Aug 4;61(4):115. doi: 10.3892/ijo.2022.5405

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Copyright: © Qian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schematic diagram of NSC-EXOs transferred miR-124-3p to inhibit glioma growth by targeting FLOT2. EXOs derived from NSCs were loaded with miR-124-3p mimics via electroporation, after deliver into glioma cells, the miR-124-3p was released by EXOs and specifically targeted the 3'-untranslated region of FLOT2 to inhibit the downstream FLOT2 expression, and then downregulated the expression of AKT1 signal pathway, finally suppressing glioma cell growth. NSC, neural stem cell; EXOs, exosomes; FLOT2, flotillin 2.