Table 2.
Continuous glucose monitoring median, minimum, maximum glucose values, and outcomes of glycemic variability in the study participants
| Descriptive outcomes, mmol/L | Glycemic variability | |||||||
|---|---|---|---|---|---|---|---|---|
| Participant | Time points, n | Days/ nights, n | Median, mmol/L | Min, mmol/L | Max, mmol/L | SD, mmol/L | Variance, mmol2/L2 | CV, % |
| 001 | ||||||||
| 24 hours | 2845 | 10 | 6.2 | 2.8 | 11.0 | 1.4 | 1.9 | 21.3 |
| 1:00-5:00 am | 480 | 10 | 7.2 | 4.9 | 11.0 | 1.1 | 1.3 | 15.7 |
| 002 | ||||||||
| 24 hours | 1206 | 4 | 5.4 | 2.2 | 9.3 | 1.2 | 1.4 | 21.5 |
| 1:00-5:00 am | 192 | 4 | 5.0 | 3.3 | 7.7 | 0.8 | 0.7 | 16.6 |
| 004 | ||||||||
| 24 hours | 2802 | 10 | 5.4 | 2.4 | 9.2 | 1.0 | 1.0 | 17.9 |
| 1:00-5:00 am | 480 | 10 | 5.4 | 3.7 | 8.2 | 0.7 | 0.5 | 13.1 |
| 006 | ||||||||
| 24 hours | 2612 | 9 | 6.7 | 2.8 | 17.0 | 1.7 | 2.8 | 24.7 |
| 1:00-5:00 am | 437 | 9 | 6.8 | 3.7 | 10.0 | 1.2 | 1.3 | 16.8 |
| 007a | ||||||||
| 24 housr | 2207 | 8 | 7.6 | 3.7 | 13.0 | 1.5 | 2.2 | 19.2 |
| 1:00-5:00 am | 384 | 8 | 8.0 | 4.6 | 12.4 | 1.7 | 2.8 | 20.6 |
| 009a | ||||||||
| 24 hours | 2851 | 10 | 5.4 | 3.0 | 10.4 | 1.3 | 1.6 | 22.2 |
| 1:00-5:00 am | 480 | 10 | 5.1 | 3.7 | 7.0 | 0.6 | 0.3 | 11.5 |
| 014 | ||||||||
| 24 hours | 2480 | 9 | 5.6 | 2.7 | 13.8 | 1.7 | 2.9 | 28.5 |
| 1:00-5:00 am | 432 | 9 | 5.0 | 3.2 | 10.0 | 1.4 | 1.9 | 25.3 |
| 015 | ||||||||
| 24 hours | 2856 | 10 | 5.7 | 2.2 | 13.9 | 1.9 | 3.5 | 32.0 |
| 1:00-5:00 am | 490 | 10 | 4.9 | 2.4 | 8.9 | 1.6 | 2.6 | 30.6 |
| 017a | ||||||||
| 24 hours | 2713 | 10 | 5.7 | 2.2 | 10.0 | 1.1 | 1.2 | 19.0 |
| 1:00-5:00 am | 480 | 10 | 5.9 | 3.2 | 8.3 | 0.9 | 0.8 | 15.0 |
| 020 | ||||||||
| 24 hours | 2932 | 10 | 5.7 | 3.2 | 9.7 | 1.0 | 0.9 | 16.7 |
| 1:00-5:00 am | 461 | 10 | 5.9 | 3.4 | 8.2 | 0.8 | 0.7 | 14.0 |
| GSDIab | ||||||||
| 24 hours | 25 504 | 90 | 5.9 (5.5-6.4) |
2.7 (2.4-3.0) |
11.7 (10.1-13.3) |
1.4 (1.2-1.6)c |
1.9 (1.4-2.5)c |
22.3 (20.0-24.6)c |
| 1:00-5:00 am | 4264 | 90 | 5.9 (5.3-6.6) |
3.6 (3.2-4.1) |
9.2 (8.1-10.3)c |
1.1 (0.8-1.3)c |
1.3 (0.7-1.9) |
17.9 (14.2-21.6)c |
| Healthy volunteersb | ||||||||
| 24 hours | 27 153 | 96 | 5.7 (5.4-6.0) |
2.8 (2.4-3.2) |
10.4 (9.9-10.9) |
1.0 (0.9-1.1) |
1.0 (0.8-1.1) |
16.5 (15.8-17.2) |
| 1:00-5:00 am | 4616 | 96 | 5.6 (5.3-6.0) |
3.7 (3.1-4.3) |
7.3 (6.6-8.0) |
0.6 (0.4-0.8) |
0.5 (0.1-0.8) |
10.7 (8.2-13.2) |
Abbreviation: CV, coefficient of variation; GSDIa, glycogen storage disease type Ia.
aGSDIa patients receiving continuous nocturnal gastric drip-feeding.
bFor descriptive and glycemic variability measures mean (95% CI) are shown.
cSignificant difference between GSDIa patients and healthy volunteers.