Table 3.
Outcomes of glycemic control in the study participants
| Participant |
Time points, n | Days/nights, n | TBR, % | TIR, % | TAR, % | |||
|---|---|---|---|---|---|---|---|---|
| <3.0 mmol/L | ≥ 3.0 to <3.9 mmol/L | ≥ 3.9 to ≤7.8 mmol/L |
≥3.9 to ≤10.0 mmol/L | >7.8 mmol/L | >10.0 mmol/L | |||
| 001 | ||||||||
| 24 hours | 2845 | 10 | 0.1 | 1.1 | 82.1 | 97.9 | 16.7 | 1.0 |
| 1:00-5:00 am | 480 | 10 | 0.0 | 0.0 | 76.9 | 96.9 | 23.1 | 3.1 |
| 002 | ||||||||
| 24 hours | 1206 | 4 | 0.6 | 5.1 | 89.6 | 94.3 | 4.7 | 0.0 |
| 1:00-5:00 am | 192 | 4 | 0.0 | 4.2 | 94.8 | 94.8 | 0.0 | 0.0 |
| 004 | ||||||||
| 24 hours | 2802 | 10 | 0.4 | 2.1 | 95.8 | 97.5 | 1.7 | 0.0 |
| 1:00-5:00 am | 480 | 10 | 0.0 | 0.4 | 98.1 | 98.8 | 0.6 | 0.0 |
| 006 | ||||||||
| 24 hours | 2612 | 9 | 0.0 | 1.0 | 80.9 | 95.6 | 17.8 | 3.2 |
| 1:00-5:00 am | 437 | 9 | 0.0 | 0.5 | 83.1 | 98.2 | 15.1 | 0.0 |
| 007c | ||||||||
| 24 hours | 2207 | 8 | 0.0 | 0.1 | 56.8 | 92.5 | 42.7 | 7.1 |
| 1:00-5:00 am | 384 | 8 | 0.0 | 0.0 | 44.3 | 86.2 | 53.6 | 11.7 |
| 009c | ||||||||
| 24 hours | 2851 | 10 | 0.0 | 3.8 | 89.3 | 95.7 | 6.6 | 0.2 |
| 1:00-5:00 am | 480 | 10 | 0.0 | 1.0 | 96.9 | 96.9 | 0.0 | 0.0 |
| 014 | ||||||||
| 24 hours | 2480 | 9 | 0.2 | 4.4 | 79.9 | 92.3 | 15.0 | 2.6 |
| 1:00-5:00 am | 432 | 9 | 0.0 | 2.8 | 88.4 | 94.4 | 6.0 | 0.0 |
| 015 | ||||||||
| 24 hours | 2856 | 10 | 1.8 | 10.7 | 73.6 | 84.1 | 13.3 | 2.8 |
| 1:00-5:00 am | 490 | 10 | 8.8 | 12.2 | 72.9 | 76.1 | 3.3 | 0.0 |
| 017c | ||||||||
| 24 hours | 2713 | 10 | 0.9 | 1.9 | 92.8 | 96.6 | 3.9 | 0.0 |
| 1:00-5:00 am | 480 | 10 | 0.0 | 1.0 | 93.8 | 95.6 | 1.9 | 0.0 |
| 020 | ||||||||
| 24 hours | 2932 | 10 | 0.0 | 1.0 | 96.1 | 99.0 | 2.9 | 0.0 |
| 1:00-5:00 am | 461 | 10 | 0.0 | 0.4 | 98.3 | 99.6 | 1.3 | 0.0 |
| GSD Iaa | ||||||||
| 24 hours | 25 504 | 90 | 0.5 (0.0-0.8) | 3.4 (1.2-5.0)b | 82.6 (76.3-91.1) | 94.2 (91.8-97.2)b | 13.5 (4.5-20.1) | 1.9 (0.3-3.1)b |
| 1:00-5:00 am | 4264 | 90 | 1.0 (0.0-2.6) | 2.2 (0.0-4.7) | 86.1 (74.4-95.2) | 95.4 (89.3-98.3)b | 10.7 (0.0-21.0) | 1.4 (0.9-6.1)b |
| Healthy volunteersa | ||||||||
| 24 hours | 27 153 | 96 | 0.2 (0.0-0.2) | 0.7 (0.3-1.1) | 92.6 (89.4-96.6) | 98.8 (98.6-99.4) | 6.4 (2.2-10.2) | 0.2 (0.1-0.3) |
| 1:00-5:00 am | 4616 | 96 | 0.1 (0.0-0.1) | 0.6 (0.0-1.4) | 95.9 (90.5-100) | 99.3 (98.5-100) | 3.3 (0.0-8.8) | 0.0 (0.0-0.0) |
For each glycogen storage disease type Ia (GSDIa) patient and cumulatively in the GSDIa study population and healthy volunteers TBR, TIR, and TAR represent the percentage of time calculated either on all time points (24 hours) or on time points within the interval 1:00-5:00 am.
Abbreviations: TBR, time below range; TIR, time in range; TAR, time above range.
aFor TBR, TIR and TAR mean and 95% CI (in brackets) are shown.
bSignificant difference between GSDIa patients and healthy volunteers.
cGSDIa patients receiving continuous nocturnal gastric drip-feeding.