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. 2022 Jun 13;107(9):2626–2635. doi: 10.1210/clinem/dgac365

Figure 2.

Figure 2.

11-Oxyandrogens are elevated in patients with lipodystrophy (LD) but not insulin receptoropathy (R) relative to healthy controls. A-G) Serum concentrations of steroid hormones differ between patients with lipodystrophy, insulin receptoropathy, and controls. H-I) Product-to-precursor ratios for 2 steroid hormone conversion reactions catalyzed by CYP11B1 in the adrenal gland, I) in the 11-oxygenated androgen pathway and G) in the classic pathway. Patients with insulin receptoropathy have decreased ratios of 11OHA4:A4 relative to controls and patients with lipodystrophy, while the ratio of cortisol:11dF is decreased in both SIR subphenotypes. P values shown for 1-way ANOVA comparison. Abbreviations and conversion factors (multiply by value to convert from nmol/L to ng/dL): 11OHA4, 11β-hydroxyandrostenedione (30.24); 11OHT, 11β-hydroxytestosterone (30.44); 11KA4, 11-ketoandrostenedione (30.04); 11KT, 11-ketotestosterone (30.24); A4, androstenedione (28.6); DHEAS, dehydroepiandrosterone sulfate (36.85); LD, lipodystrophy; R, insulin receptoropathy; T, testosterone (28.8).