Table 3.
Relative composition of phospholipid and sphingolipid classes in HDL fractions
| T2D patients (n = 20) |
Controls (n = 25) |
P value | |
|---|---|---|---|
| Glycerophospholipids (nmol/mg) | |||
| PC/apoAI | 913 ± 149 | 877 ± 206 | 0.307 |
| LPC/apoAI | 31.2 ± 11.8 | 24.6 ± 7.2 | 0.280 |
| PE/apoAI | 5.00 ± 2.17 | 3.55 ± 1.77 | 0.026 |
| LPE/apoAI | 1.21 ± 0.057 | 0.96 ± 0.44 | 0.077 |
| LPC + LPE/apoAI | 32.4 ± 12.2 | 25.6 ± 7.5 | 0.060 |
| PI/apoAI | 36.6 ± 12.8 | 29.9 ± 12.2 | 0.073 |
| PE-based plasmalogens/apoAI | 1.26 ± 0.63 | 1.73 ± 0.88 | 0.038 |
| Sphingolipids (nmol/mg) | |||
| SM/apoAI | 96 ± 30 | 103 ± 33 | 0.483 |
| Cer/apoAI | 0.387 ± 0.136 | 0.512 ± 0.206 | 0.053 |
| S1P/apoAI | 0.068 ± 0.020 | 0.071 ± 0.012 | 0.689 |
Data are presented as mean ± SD. The value for each phospho- or sphingolipid class is the sum of the different species belonging to this class. Statistical analysis has been performed on the sums, representing a unique value for each class.
Abbreviations: apoAI, apolipoprotein AI; Cer, ceramide; PC, phosphatidylcholine; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; S1P, sphingosine-1-phosphate; SM, sphingomyelin.