. 2022 Jun 11;107(9):e3747–e3758. doi: 10.1210/clinem/dgac361

Table 4.

Associations of changes in bone turnover markers and bone parameters with changes in body composition measures, sex steroids, and enteric peptides over 12-months in cohort with female participants only

12-month change	BMI	Lean Mass	Estrone	FAI	Sclerostin	Ghrelin
	ρ	ρ	ρ	ρ	ρ	ρ
Bone turnover markers
P1NP	–0.455 ^* ^, ^a	–0.251	–0.042	0.060	0.546 ^*	–0.306
CTX	–0.559 ^* ^, ^a	–0.571 ^* ^, ^a	–0.173	–0.112	0.401 ^* ^, ^a	–0.423 ^* ^, ^a
DXA
LS BMD Z-scores	0.212	0.202	0.170	0.342 ^*	–0.089	0.198
Total hip BMD Z-scores	0.699 ^* ^, ^a	0.735 ^* ^, ^a	0.387 ^* ^, ^a	0.425 ^* ^, ^a	–0.165^a	0.358 ^*
FN BMD Z-scores	0.463 ^* ^, ^a	0.502 ^* ^, ^a	0.257^a	0.089	–0.052	0.352 ^* ^, ^a
Whole body BMD Z-scores	–0.273	–0.063	0.147	0.163	–0.005	0.024
HRpQCT
Radius
Total vBMD	0.404 ^* ^, ^a	0.277	0.263	–0.000	0.043	0.070
Cortical vBMD	–0.105	–0.252	0.098	0.058	0.076	–0.287
Trab vBMD	0.617 ^* ^, ^a	0.424 ^* ^, ^a	0.128	–0.013	–0.100	0.341 ^a
Failure load	0.156	0.040	0.111	0.220	–0.050	0.222
Tibia
Total vBMD	0.342 ^* ^, ^a	0.285	0.221	0.085^a	–0.217	0.280
Cortical vBMD	–0.113	–0.142	–0.095	–0.350 ^*	–0.380 ^*	0.068
Trabecular vBMD	–0.034	–0.086	0.215	0.053^a	–0.057	0.012
Failure load	0.109	0.091	0.257	–0.110	–0.138	–0.012

Spearman correlations (ρ) are reported.

Abbreviations: BMI, body mass index; BMD, bone mineral density; FAI, free androgen Index; P1NP, N-terminal propeptide of type 1 procollagen; CTX, C-terminal cross-linking telopeptide; LS, lumbar spine; FN, femoral neck; vBMD, volumetric bone mineral density.

*P < 0.05 (also in bold);

^a P < .05 after controlling for baseline age and race.