Table 2.
Additive model association results for phosphate among all individuals (n = 3027)
| General White population (6, 26) | CRIC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNV | Host/Adjacent gene | Minor allele | MAF | Model 1c | Model 2c | Model 3c | |||||
| β (SE)a | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | ||||
| rs1697421 |
ALPL
NBPF3 |
A | 0.35 | 0.044 | 3 × 10–16 | 0.01 (–0.03 to 0.05) |
.67 | 0.001 (–0.03 to 0.03) |
.99 | –0.001 (–0.035 to 0.033) |
.94 |
| rs1801725 | CASR | A | 0.14 | –0.01 (0.0006) |
1 × 10–81 | –0.06 (–0.11 to –0.01) |
.04 | –0.04 (–0.09 to 0.01) |
.15 | –0.033 (–0.084 to 0.017) |
.19 |
| rs4074995 | RGS14 | A | 0.21 |
–0.008
(0.0004) |
3 × 10 –87 |
–0.09
(–0.14 to –0.04) |
3 × 10 -4 |
–0.09
(–0.13 to –0.04) |
5 × 10 -4 |
–0.048
(–0.086 to –0.010) |
.01 |
| rs9469578 | IHPK3 | T | 0.13 | –0.064 | 5 × 10–10 | –0.03 (–0.11 to 0.05) |
.50 | –0.05 (–0.12 to 0.03) |
.23 | –0.04 (–0.10 to 0.02) |
.16 |
| rs453639 | ENPP3 | C | 0.25 | 0.036 | 4 × 10–7 | 0.01 (–0.03 to 0.05) |
.58 | 0.02 (–0.02 to 0.06) |
.33 | 0.02 (–0.02 to 0.06) |
.36 |
| rs947583 | PDE7B | C | 0.28 | 0.035 | 2 × 10–9 | –0.01 (–0.05 to 0.03) |
.63 | –0.01 (–0.05 to 0.03) |
.64 | 0.01 (–0.03 to 0.04) |
.64 |
| rs11063205b | C12orf4 | A | 0.09 | 0.052 | 4 × 10–8 | –0.04 (–0.16 to 0.08) |
.52 | –0.06 (–0.17 to 0.05) |
.29 | –0.003 (–0.06 to 0.06) |
.92 |
| rs10799702 | ALPL | G | 0.39 | –0.01 (0.0004) |
5 × 10–239 | 0.0002 (–0.03 to 0.03) |
.99 | 0.01 (–0.02 to 0.04) |
.54 | 0.01 (–0.02 to 0.04) |
.45 |
| rs17145704 | LINC00709 | G | 0.12 | –0.01 (0.0007) |
4 × 10–22 | 0.01 (–0.06 to 0.09) |
.73 | 0.03 (–0.04 to 0.10) |
.43 | 0.05 (0.003 to 0.09) |
.04 |
| rs209957 | CYP24A1 | G | 0.23 | 0.003(0.0004) | 1 × 10–14 | 0.004 (–0.04 to 0.05) | .86 | 0.02 (–0.03 to 0.06) | .43 | 0.05 (0.01 to 0.08) | .01 |
Abbreviations: BMI, body mass index; CRIC, Chronic Renal Insufficiency Cohort; eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor 23; MAF, minor frequency allele; PTH, parathyroid hormone; SNV, single-nucleotide variation.
a SEs unavailable in original genome-wide association studies (Kestenbaum et al) (6); SEs provided for SNVs from the UK Biobank.
b rs11063205 is proxy for rs2970818 (R2 = 0.7).
c Bonferroni-corrected significance threshold = 0.005.
Model 1 includes age, sex, and first 10 principal components of ancestry.
Model 2 includes model 1 + eGFR and eGFR-squared + BMI.
Model 3 includes model 2 + calcium, PTH, and FGF23.
Bolded values are those reaching significance.