Table 1. Background characteristics of the study population.
| First author | Country | Method | Subjects | Sex M/F |
Cell type/location | Study group | Control group | SPARC | Outcome | Obtainment | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| + | - | ||||||||||
| Huang, et al. 2017 [35] | China | qPCR | 120 | 110/10 | Tumor | HCC tumor tissues | Tumor adjacent liver tissues | 71 | 49 | OS、DFS | Multivariate |
| Liu 2020 [36] |
China | IHC | 89 | 36/7 | Stroma | Patients with HCC | Healthy controls | 11 | 78 | OS | Multivariate |
| Yang 2018 [37] |
China | IHC | 79 | 38/16 | Tumor | Patients with primary liver cancer | Tumor adjacent liver tissues | 35 | 44 | OS、DFS | Multivariate |
| Ju 2009 [32] |
China | qPCR | 130 | 112/18 | Tumor | Patients with HCC | Healthy liver donors | 85 | 45 | OS、RFS | Multivariate |
| Zhang 2012 [33] |
China | MSP | 60 | 9/51 | Tumor | HCC tumor tissues | Nontumorous liver tissues | 21 | 39 | OS | Multivariate |
| Darweesh 2018 [38] |
Egypt | qPCR | 200 | 160/40 | Tumor | Patients with HCC | Healthy controls | NA | NA | OS | Multivariate |