Table 1. Genetic variants in FGFRL1 associated with height, hypertension and osteoporosis.
| SNP | Minor allele | MAF | Function | Height | HTN | Osteoporosis | |||
|---|---|---|---|---|---|---|---|---|---|
| β ± s.e | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | ||||
| rs117864192 | A | 0.031 | intron | -0.249 ± 0.087 | 4.17 × 10 −3 | 1.013 (0.935–1.098) | 0.749 | 0.966 (0.829–1.126) | 0.658 |
| rs73219733 | T | 0.029 | intron | -0.251 ± 0.091 | 5.83 × 10 −3 | 1.008 (0.926–1.097) | 0.855 | 0.999 (0.849–1.175) | 0.987 |
| rs748650 | A | 0.255 | intron | -0.090 ± 0.035 | 9.77 × 10 −3 | 1.017 (0.984–1.050) | 0.315 | 1.047 (0.984–1.113) | 0.146 |
| rs115259783 | G | 0.157 | intron | 0.105 ± 0.041 | 0.011 | 0.979 (0.942–1.018) | 0.287 | 1.031 (0.958–1.109) | 0.421 |
| rs34627176 | A | 0.044 | upstream | -0.177 ± 0.074 | 0.017 | 0.967 (0.903–1.036) | 0.345 | 0.959 (0.839–1.096) | 0.537 |
| rs139932728 | A | 0.021 | upstream | 0.248 ± 0.104 | 0.017 | 1.005 (0.913–1.106) | 0.924 | 1.115 (0.931–1.335) | 0.237 |
| rs3733350 | T | 0.101 | 3’-UTR | 0.113 ± 0.050 | 0.025 | 0.959 (0.915–1.005) | 0.078 | 1.047 (0.959–1.143) | 0.310 |
| rs4647936 | T | 0.030 | 3’-UTR | -0.192 ± 0.089 | 0.030 | 1.053 (0.970–1.143) | 0.215 | 0.928 (0.791–1.088) | 0.358 |
| rs77488513 | T | 0.030 | upstream | -0.180 ± 0.088 | 0.042 | 1.059 (0.976–1.149) | 0.170 | 0.917 (0.781–1.076) | 0.286 |
| rs13143527 | G | 0.291 | intron | -0.063 ± 0.033 | 0.057 | 0.967 (0.937–0.997) | 0.031 | 0.939 (0.885–0.997) | 0.039 |
| rs55639339 | T | 0.140 | intron | -0.015 ± 0.044 | 0.736 | 1.043 (1.002–1.086) | 0.041 | 1.103 (1.023–1.190) | 0.011 |
| rs10010999 | T | 0.348 | upstream | -0.028 ± 0.032 | 0.370 | 0.971 (0.942–0.999) | 0.047 | 0.977 (0.924–1.034) | 0.418 |
| rs74921869 | A | 0.253 | intron | 0.033 ± 0.035 | 0.343 | 1.015 (0.983–1.048) | 0.362 | 1.093 (1.028–1.161) | 4.35 × 10 −3 |
| rs35220088 | C | 0.309 | intron | -0.003 ± 0.033 | 0.924 | 1.001 (0.972–1.032) | 0.926 | 1.084 (1.024–1.148) | 5.86 × 10 −3 |
| rs73070422 | G | 0.140 | intron | -0.015 ± 0.044 | 0.723 | 1.041 (0.999–1.083) | 0.053 | 1.087 (1.008–1.173) | 0.031 |
| rs78590462 | T | 0.066 | intron | -0.065 ± 0.061 | 0.287 | 1.019 (0.963–1.079) | 0.505 | 0.892 (0.798–0.997) | 0.044 |
Age, sex and body mass index (BMI) were included as covariants in all genetic models. SNPs indicated in bold are associated with both hypertension and osteoporosis at P < 0.05. Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; HTN, hypertension; β, regression coefficient; s.e, standard error; OR, odds ratio; CI, confidence interval.