Table 2. Genetic variants in the FGF family associated with two of the three phenotypic traits (height, hypertension, and osteoporosis) or below the Bonferroni-corrected significance level.

Gene	Chr	SNP	Minor allele	MAF	Function	Height		HTN		Osteoporosis
						β ± s.e	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
FGF2	4	rs167428	C	0.087	intron	0.112 ± 0.054	0.037	1.040 (0.99–1.09)	0.122	1.131 (1.03–1.24)	8.59 × 10 −3
	4	rs308387	A	0.052	intron	0.234 ± 0.068	5.85 × 10 −4	1.023 (0.96–1.09)	0.487	1.062 (0.94–1.20)	0.317
FGF4	11	rs58166091	A	0.213	-	0.114 ± 0.037	2.16 × 10 −3	0.989 (0.96–1.02)	0.544	1.026 (0.96–1.10)	0.436
FGF10	5	rs17227836	C	0.054	intron	-0.161 ± 0.067	0.016	0.993 (0.93–1.06)	0.816	1.144 (1.02–1.28)	0.021
	5	rs13154419	G	0.412	intron	0.112 ± 0.031	2.89 × 10 −4	0.991 (0.96–1.02)	0.545	0.988 (0.94–1.04)	0.674
	5	rs1448039	A	0.500	intron	-0.094 ± 0.030	1.90 × 10 −3	1.006 (0.98–1.04)	0.653	1.017 (0.96–1.07)	0.528
FGF18	5	rs10463007	T	0.404	-	0.081 ± 0.031	9.26 × 10 −3	0.990 (0.96–1.02)	0.498	1.071 (1.01–1.13)	0.014
FGF22	19	rs8109113	G	0.024	intron	-0.241 ± 0.100	0.016	0.901(0.82–0.99)	0.028	1.021 (0.85–1.22)	0.824

Age, sex and body mass index (BMI) were included as covariant in all genetic models. Findings with P < 0.05 are indicated in bold. The p-values which satisfied the Bonferroni-corrected significance level regarding each gene are indicated in bold and underlined. Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; HTN, hypertension; β, regression coefficient; s.e, standard error; OR, odds ratio; CI, confidence interval.