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. 2022 Aug 18;17(8):e0273049. doi: 10.1371/journal.pone.0273049

Fig 1. The effects of a high-fat diet and voluntary wheel running (VWR) on body weight, food intake.

Fig 1

C57BL/6 mice were fed a high-fat diet (HFD), a high-fat fed with VWR (HFX), and corresponding control diet (CON) for 12 weeks. (A) The body weight curve of the CON, HFD, and HFX group was monitored. (B) Weekly food intake of the CON, HFD, and HFX group for 12 weeks. (C) The ratio of weekly average food intake to body weight for all experimental groups. (D) Distribution of food intake for all experimental groups. The data represent means ± SEM of (A-D) n = 9, the control group (CON); n = 9, the high-fat diet group (HFD); n = 12, the high-fat diet VWR group (HFX). **P<0.01, ***P<0.001 compared with CON and ##P<0.01, ###P<0.001 compared with HFD, using two-way ANOVA with Tukey-Kramer post-hoc test with a standard significance threshold (P<0.05) (A-D).