Table 5. Summary of Key UV-4 Pharmacokinetic Parameters.
| UV-4 Dose and Number in Cohort (N) | ||||||||
|---|---|---|---|---|---|---|---|---|
| PK Parameters Statistics | 3 mg (N = 6) | 10 mg (N = 6) | 30 mg (N = 6) | 90 mg (N = 6) | 180 mg (N = 6) | 360 mg (N = 6) | 720 mg (N = 6) | 1000 mg (N = 6) |
| AUC(0-inf) (h*ng/mL) | ||||||||
| Arithmetic Mean | 95.6 | 431 | 1261.7 | 3728.3 | 7110 | 13833.3 | 32916.7 | 43083.3 |
| CV (%) | 16.3 | 26.7 | 9.6 | 13.8 | 8.1 | 14.1 | 10.7 | 13.5 |
| Geometric Mean | 94.6 | 420.1 | 1256.4 | 3700.5 | 7090.4 | 13714.7 | 32756.2 | 42765.2 |
| Cmax (ng/mL) | ||||||||
| Arithmetic Mean | 22.4 | 84.6 | 292.5 | 945.5 | 2148.3 | 4568.3 | 9925 | 13133.3 |
| CV (%) | 15.9 | 23.4 | 15.3 | 34.9 | 28.8 | 19.7 | 20.7 | 17.1 |
| Geometric Mean | 22.1 | 82.6 | 289.1 | 899.8 | 2062.6 | 4494.6 | 9758.9 | 12993.2 |
| Half-Life (h) | ||||||||
| Arithmetic Mean | 10.7 | 12 | 10 | 10.4 | 8.7 | 8.1 | 8.2 | 8.8 |
| CV (%) | 33.2 | 10.4 | 7.6 | 27.1 | 11.2 | 9.7 | 6.9 | 27.9 |
| Geometric Mean | 10.3 | 11.9 | 10 | 10.2 | 8.7 | 8.1 | 8.2 | 8.6 |
| Tmax (h) | ||||||||
| Median | 0.5 | 1 | 0.5 | 0.5 | 0.8 | 0.5 | 0.8 | 1 |
| Minimum | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Maximum | 1 | 1.5 | 1 | 1.5 | 1 | 1 | 1 | 1.5 |