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. 2022 Aug 4;10:923170. doi: 10.3389/fpubh.2022.923170

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Copyright © 2022 Feng, Dai, Liu, Li, Gou, Chen, Chen and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic workflow for the experimental approach using untargeted metabolomics. The plasma were collected from NC, MT and MTS groups for metabolomics profiling using untargeted metabolomics. Quantitative information is extracted from MS data and identification based on database, and the metabolic pathways of differential metabolites were enriched and the potential biomarkers were further obtained, subsequently, the availability was predicted and the correlations between potential biomarkers and clinical characteristics were analyzed.