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. 2022 Aug 4;10:923170. doi: 10.3389/fpubh.2022.923170

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Copyright © 2022 Feng, Dai, Liu, Li, Gou, Chen, Chen and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatter and trend plot of 16 potential biomarkers in the ESI+ and ESI- models. The scatter and trend plot of acrylic acid (A), 3b-hydroxy-5-cholenoic acid (B), 5-amino-3-oxohexanoate (C), cytidine (D), D-ribose (E), L-glutamic acid (F), PE [P-18:1(9Z)/16:1(9Z)] (G), PE [P-18:1(9Z)/20:3(5Z,8Z,11Z)] (H), PE [P-18:1(11Z)/18:2(9Z,12Z)] (I), PE [P-18:1(11Z)/18:3(6Z,9Z,12Z)] (J), sorbitol (K), sphinganine (L), succinic acid semialdehyde (M), succinic acid (N), uracil (O), and uridine (P), and the ordinate was the relative intensity of metabolite. (Q,R) Receiver operator curve (ROC) analysis of the random forest model combining 12 biomarkers (P < 0.05) to diagnose MTS in the validation data. *P < 0.05, **P < 0.01.