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. 2022 Jul 21;28(8):1630–1639. doi: 10.1038/s41591-022-01897-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a Characteristic MRI changes are observed with an overall lesion size increased during the administration period. b Shrinkage of the target lesion is observed at 12 months after the last G47Δ administration. c Cerebrospinal fluid (CSF) dissemination is observed in the brain and in the spinal cord at 35 months after the last G47Δ administration. Note that the target lesion is well controlled. The disease course since the initiation of G47Δ therapy was 55.2 months.