Figure 2.

Tissue-specific ELP1 splicing rescue in FD mice

(A and B) Endpoint PCR histograms of ELP1 splicing isoforms in FD animals (Ikbkap^Δ20/Ikbkap^flox; h-TgFD9/+) treated with saline (in orange) and AAV9-U1-FD (in blue) at PND-10 and PND-90, respectively, in (A) and in (B). Data are expressed as percentage of exon 20 inclusion. DRG, dorsal root ganglia; TG, trigeminal ganglia; SCG, superior cervical ganglia; SC, spinal cord. In the graph, data are reported as mean ± SEM, for each group 5 animals were tested (except for SCG and TG in which 3 animals per group were tested). Statistical analysis was performed by two-way ANOVA. Asterisks indicate the comparison for the saline group versus treated group in FD mice. ns, not significant; ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001; ^∗∗∗∗p < 0.0001.