Figure 3.

AAV9-U1-FD treatment rescues ELP1 levels in FD mice

Quantification of ELP1 levels in control mice (Ikbkap^flox/+; h-TgFD9/+; black columns), FD mice (Ikbkap^Δ20/Ikbkap^flox; h-TgFD9/+; orange columns), and FD mice treated with AAV9-U1-FD (Ikbkap^Δ20/Ikbkap^flox; h-TgFD9/+; blue columns) at two different time points, PND-10 and PND-90, in different tissues: (A) brain, (B) dorsal root ganglia, (C) trigeminal ganglia, (D) spinal cord, (E) liver, (F) heart, (G) muscle. GAPDH was used as internal reference control. Data are expressed as mean ± SEM; 3 mice for each group were tested, except for controls and trigeminal ganglia groups in which 2 animals were analyzed. Western blots used for quantitative analysis are shown in Figure S3. Statistical analysis was performed using two-way ANOVA with Bonferroni correction. ns, not significant; ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001; ^∗∗∗∗p < 0.0001.