Fig. 3.

Durability of elamipretide-induced cardiac benefit in mice with diastolic dysfunction [62]. In old mice with LV diastolic dysfunction, treatment with elamipretide for 8 weeks normalized diastolic functional deficit, as evidenced by an increase in Ea/Aa. Improvement in diastolic function was associated with normalization of mitochondrial proton leak, reduced mitochondrial ROS, and reduced protein oxidation overall as well as at the cellular level. Exercise tolerance also improved. Ea/Aa improvement was maintained for up to 2 weeks after withdrawal of elamipretide. Used with permission from [62]. Abbreviations: Ea/Aa ratio of early-to-late diastolic mitral annulus velocities, ROS reactive oxygen species