Table 2.
Connectivity analyses
ROI to ROI connection | Statistics | p-qFDR | ||||||
---|---|---|---|---|---|---|---|---|
A | ROI-to-ROI rs-fc differences between the 3 groups | |||||||
Group effect | F(8,310) = 2.59 | 0.48 | ||||||
Post hoc analyses | ||||||||
Paranoia vs healthy control groups ø | ||||||||
Non-paranoia vs healthy control groups ø | ||||||||
Paranoia vs non-paranoia groups | F(3,81) = 4.84 | 0.022 | ||||||
Hippo_R-Amygdala_L |
T(81) = 2.35 T(81) = 2.01 |
0.021 0.047 |
||||||
Hippo_L-Amygdala_R | ||||||||
B | ROI-to-ROI rs-fc changes with paranoia severity | F(3,81) = 7.10 | 0.001 | |||||
Hippo_R -Amygdala_R Hippo_R -Amygdala_L Hippo_L -Amygdala_L Hippo_L -Amygdala_R |
T(83) = 3.26 T(83) = 3.06 T(83) = 2.29 T(83) = 2.29 |
0.001 0.003 0.029 0.029 |
ROI | Cluster peak (x, y, z) | BA | Size | Cluster p-FWE | Cluster p-qFDR | |||
---|---|---|---|---|---|---|---|---|
C | ROI-to-voxels rs-fc differences between the 3 groups | |||||||
Group effect ø | ||||||||
Exploratory analysis paranoia vs non-paranoia groups | ||||||||
Left sup OFC | − 50 + 28 − 08 | BA 47 | 240 | 0.003 | 0.002 | |||
Right sup OFC | −38 −71 + 48 | BA 39 | 252 | 0.002 | 0.002 | |||
D | ROI-to-voxels rs-fc changes with paranoia severity | |||||||
Left sup OFC | + 36 + 24 −16 | BA 187 | 94 | 0.016 | 0.015 | |||
Left sup OFC | −46 + 22 −18 | BA 156 | 94 | 0.046 | 0.021 |
BA broadman area, hippo hippocampus, OFC orbitofrontal cortex, R right, L left