Table 2.
Differences in fractional anisotropy in the Johns Hopkins University White-Matter Tractography Atlas-based tract
| Cohort (1) | Post hoc comparison (HC vs SZ-HCP-C1) (HC vs SZ-LCP-C1) (SZ-HCP-C1 vs SZ-LCP-C1) |
Cohort (2) | Post hoc comparisons (HC vs SZ-HCP-C2) (HC vs SZ-LCP-C2) (SZ-HCP-C2 vs SZ-LCP-C2) |
|||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC | SZ | p | SZ-HCP-C1 | SZ-LCP-C1 | p | HC | SZ | p | SZ2-HCP-C2 | SZ-LCP-C2 | p | |||||||||||
| Left anterior thalamic radiation, mean (sd) | 0.482 | 0.015 | 0.472 | 0.019 | 0.005* | 0.475 | 0.020 | 0.486 | 0.017 | 0.013* |
(0.154) (0.013*) (1.000) |
0.449 | 0.014 | 0.442 | 0.025 | 0.083 | 0.449 | 0.025 | 0.435 | 0.025 | 0.013* |
(1.000) (0.015*) (0.054) |
| Right anterior thalamic radiation, mean (sd) | 0.471 | 0.018 | 0.461 | 0.018 | 0.031* | 0.463 | 0.019 | 0.459 | 0.018 | 0.072 | 0.437 | 0.015 | 0.431 | 0.024 | 0.155 | 0.436 | 0.026 | 0.427 | 0.023 | 0.117 | ||
| Left cingulum cingulate gyrus, mean (sd) | 0.634 | 0.031 | 0.618 | 0.032 | 0.046* | 0.628 | 0.028 | 0.609 | 0.034 | 0.020* |
(1.000) (0.019*) (0.147) |
0.609 | 0.029 | 0.603 | 0.041 | 0.394 | 0.612 | 0.039 | 0.594 | 0.042 | 0.143 | |
| Right cingulum cingulate gyrus, mean (sd) | 0.592 | 0.032 | 0.574 | 0.044 | 0.067 | 0.579 | 0.040 | 0.570 | 0.048 | 0.168 | 0.566 | 0.037 | 0.561 | 0.043 | 0.438 | 0.566 | 0.041 | 0.555 | 0.046 | 0.517 | ||
| Left cingulum hippocampus, mean (sd) | 0.559 | 0.044 | 0.549 | 0.063 | 0.554 | 0.561 | 0.061 | 0.537 | 0.064 | 0.087 | 0.509 | 0.049 | 0.489 | 0.049 | 0.020* | 0.482 | 0.057 | 0.496 | 0.039 | 0.043* |
(0.043*) (0.551) (1.000) |
|
| Right cingulum hippocampus, mean (sd) | 0.562 | 0.062 | 0.554 | 0.063 | 0.735 | 0.555 | 0.079 | 0.554 | 0.061 | 0.670 | 0.502 | 0.050 | 0.493 | 0.049 | 0.178 | 0.492 | 0.052 | 0.493 | 0.047 | 0.400 | ||
| Left corticospinal tract, mean (sd) | 0.637 | 0.020 | 0.630 | 0.020 | 0.100 | 0.631 | 0.022 | 0.628 | 0.019 | 0.253 | 0.585 | 0.025 | 0.582 | 0.028 | 0.790 | 0.590 | 0.026 | 0.574 | 0.028 | 0.195 | ||
| Right corticospinal tract, mean (sd) | 0.637 | 0.021 | 0.632 | 0.025 | 0.369 | 0.632 | 0.029 | 0.633 | 0.022 | 0.575 | 0.602 | 0.026 | 0.593 | 0.031 | 0.309 | 0.598 | 0.029 | 0.588 | 0.032 | 0.481 | ||
| Forceps major, mean (sd) | 0.706 | 0.019 | 0.694 | 0.031 | 0.094 | 0.694 | 0.031 | 0.693 | 0.032 | 0.247 | 0.692 | 0.022 | 0.679 | 0.027 | 0.034* | 0.685 | 0.028 | 0.674 | 0.025 | 0.057 | ||
| Forceps minor, mean (sd) | 0.584 | 0.023 | 0.567 | 0.027 | < 0.001*** | 0.574 | 0.028 | 0.56 | 0.025 | 0.002** |
(0.033*) (0.003**) (1.000) |
0.577 | 0.029 | 0.566 | 0.028 | 0.120 | 0.577 | 0.027 | 0.554 | 0.025 | 0.017* |
(1.000) (0.021*) (0.049*) |
| Left inferior fronto-occipital fascicles, mean (sd) | 0.560 | 0.023 | 0.534 | 0.023 | < 0.001*** | 0.537 | 0.021 | 0.531 | 0.025 | < 0.001*** |
(0.002**) (< 0.001***) (1.000) |
0.530 | 0.021 | 0.517 | 0.025 | 0.014* | 0.528 | 0.025 | 0.507 | 0.019 | < 0.001*** |
(1.000) (< 0.001***) (0.007**) |
| Right inferior fronto-occipital fascicles, mean (sd) | 0.551 | 0.023 | 0.540 | 0.023 | 0.055 | 0.545 | 0.018 | 0.536 | 0.027 | 0.102 | 0.525 | 0.021 | 0.516 | 0.028 | 0.112 | 0.528 | 0.027 | 0.503 | 0.022 | < 0.001*** |
(1.000) (0.002**) (0.002**) |
|
| Left inferior longitudinal fascicles, mean (sd) | 0.555 | 0.023 | 0.533 | 0.027 | < 0.001*** | 0.536 | 0.024 | 0.531 | 0.030 | 0.004** |
(0.020*) (0.008**) (1.000) |
0.515 | 0.025 | 0.504 | 0.024 | 0.053 | 0.512 | 0.024 | 0.495 | 0.02 | 0.020* |
(1.000) (0.017**) (0.130) |
| Right inferior longitudinal fascicles, mean (sd) | 0.573 | 0.023 | 0.563 | 0.029 | 0.115 | 0.566 | 0.026 | 0.560 | 0.033 | 0.274 | 0.524 | 0.024 | 0.515 | 0.026 | 0.183 | 0.527 | 0.024 | 0.503 | 0.024 | 0.006** |
(1.000) (0.014*) (0.011*) |
|
| Left superior longitudinal fascicles, mean (sd) | 0.522 | 0.023 | 0.506 | 0.024 | 0.006* | 0.507 | 0.026 | 0.505 | 0.024 | 0.023* |
(0.044*) (0.076) (1.000) |
0.497 | 0.025 | 0.487 | 0.025 | 0.097 | 0.490 | 0.026 | 0.484 | 0.024 | 0.245 | |
| Right superior longitudinal fascicles, mean (sd) | 0.522 | 0.025 | 0.511 | 0.025 | 0.100 | 0.507 | 0.027 | 0.516 | 0.023 | 0.102 | 0.512 | 0.027 | 0.503 | 0.028 | 0.158 | 0.509 | 0.028 | 0.497 | 0.027 | 0.183 | ||
| Left superior longitudinal fascicles, temporal part, mean (sd) | 0.568 | 0.027 | 0.553 | 0.027 | 0.023 | 0.552 | 0.027 | 0.553 | 0.027 | 0.068 | 0.536 | 0.029 | 0.527 | 0.029 | 0.211 | 0.527 | 0.032 | 0.527 | 0.026 | 0.420 | ||
| Right superior longitudinal fascicles, temporal part, mean (sd) | 0.560 | 0.031 | 0.553 | 0.028 | 0.290 | 0.549 | 0.027 | 0.558 | 0.028 | 0.256 | 0.541 | 0.031 | 0.534 | 0.028 | 0.305 | 0.538 | 0.031 | 0.529 | 0.025 | 0.445 | ||
| Left uncinate fascicles, mean (sd) | 0.549 | 0.036 | 0.521 | 0.032 | < 0.001*** | 0.526 | 0.033 | 0.516 | 0.029 | 0.003** |
(0.038*) (0.004**) (1.000) |
0.487 | 0.028 | 0.481 | 0.035 | 0.239 | 0.487 | 0.034 | 0.476 | 0.035 | 0.209 | |
| Right uncinate fascicles, mean (sd) | 0.582 | 0.033 | 0.562 | 0.038 | 0.027 | 0.562 | 0.038 | 0.561 | 0.039 | 0.084 | 0.524 | 0.035 | 0.513 | 0.039 | 0.125 | 0.515 | 0.042 | 0.511 | 0.037 | 0.286 | ||
One-way ANOVA and Bonferroni’s post hoc test with age and sex as covariates. Significant differences among the three groups are marked. Values marked with ***, ** and * are significant at p < 0.05/40 = 0.00125, p < 0.01 and p < 0.05, respectively