Table 1.
Baseline patient characteristics according to hematologic response status at the time of kidney transplantation.
| Characteristic | Overall (N = 237) | TN (N = 17) | CR (N = 145) | VGPR (N = 40) | PR (N = 24) | NR (N = 11) |
|---|---|---|---|---|---|---|
| Age at diagnosis (years; median) | 55 (26–74;) | 60 (34–74;) | 54 (27–70) | 54 (30–74) | 53 (37–70) | 55 (41–64) |
| Male | 156 (65.8%) | 12 (70.6%) | 91 (62.8%) | 27 (67.5%) | 19 (79.2%) | 7 (63.6%) |
| Race: white | 228 (96%) | 17 (100%) | 140 (96%) | 38 (95%) | 23 (95%) | 10 (100%) |
| FLC type | ||||||
| Kappa | 80 (34%) | 6 (35%) | 50 (35%) | 10 (25%) | 10 (42%) | 4 (36%) |
| Lambda | 157 (66%) | 11 (65%) | 95 (65%) | 30 (75%) | 14 (59%) | 7 (64%) |
| Creatinine at diagnosis (µmol/L) | 176 (35–1414) | 190 (62–539) | 197 (35–1414) | 108 (35–1061) | 135 (62–875) | 163 (53–371) |
| eGFR MDRD at diagnosis | 35.5 (2–139) | 27 (9–97) | 30 (2–139) | 59 (4–135) | 61.5 (6–127) | 42 (16–124) |
| Proteinuria (grams/24 hr) | 7 (0–41.8) | 3.7 (0.2–26) | 7.235 (0–41.8) | 5.6 (0–17.6) | 7.99 (0–23.2) | 7.4 (0–15.3) |
| Co-morbidities | ||||||
| DM | 9 (3.8%) | 0 (0.0%) | 7 (4.9%) | 1 (2.6%) | 1 (4.2%) | 0 (0.0%) |
| Hypertension | 76 (32.3%) | 8 (47.1%) | 41 (28.5%) | 16 (41%) | 10 (41.7%) | 1 (9.1%) |
| Vascular disease (CAD, MI, PAD) | 21 (8.9%) | 2 (11.8%) | 14 (9.7%) | 4 (10.3%) | 0 (0.0%) | 1 (9.1%) |
| Organ involvement | ||||||
| Cardiac | 96 (40.5%) | 5 (29.4%) | 57 (39.3%) | 21 (52.5%) | 8 (33.3%) | 5 (45.5%) |
| Renal | 226 (95.4%) | 17 (100%) | 136 (93.8%) | 38 (95%) | 24 (100%) | 11 (100%) |
| Hepatic | 55 (23.2%) | 4 (23.5%) | 34 (23.4%) | 8 (20%) | 9 (37.5%) | 0 (0.0%) |
| GI | 38 (16%) | 3 (17.6%) | 20 (13.8%) | 8 (20%) | 5 (20.8%) | 2 (18.2%) |
| AN | 27 (11.4%) | 3 (17.6%) | 11 (7.6%) | 6 (15%) | 5 (20.8%) | 2 (18.2%) |
| PN | 36 (15.2%) | 4 (23.5%) | 17 (11.7%) | 7 (17.5%) | 6 (25%) | 2 (18.2%) |
| Pulmonary | 2 (0.8%) | 0 (0.0%) | 1 (0.7%) | 1 (2.5%) | 0 (0.0%) | 0 (0.0%) |
| Multi organ involvement | 162 (68.4%) | 9 (52.9%) | 95 (65.5%) | 31 (77.5%) | 18 (75%) | 9 (81.8%) |
| Type of renal transplantation | ||||||
| Living | 131 (54%) | 14 (87.5%) | 82 (57.7%) | 23 (60.5%) | 8 (36.4%) | 4 (36.4%) |
| Cadaveric | 106 (46%) | 3 (18%) | 63 (43%) | 17 (42%) | 16 (66%) | 7 (63.6%) |
CR complete response, VGPR very good partial response, PR partial response, NR no response, TN treatment naive.